Effect of Ukrain on human liver alcohol dehydrogenase activity in vitro.

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Jagie??o-Wójtowicz E, Dudka J, Dawidek-Pietryka K.

Department of Toxicology, University Medical School, Chodki 7, 20-093 Lublin, Poland.

In the present study it was found that Ukrain inhibits the ethanol oxidation process catalyzed by human alcohol dehydrogenase (ADH). Ukrain at a concentration of 10(-6), 2.5 x 10(-6), and 5.0 x 10(-6) M decreased liver ADH activity in the presence ethanol (approximately 8.41%, 13.28%, 16.69%, respectively) as well as in the presence of methanol (approximately 13.29%, 19.07% and 42.20%, respectively).