Drugs Exp Clin Res. 1992;18 Suppl:101-5.
Modification of antinociceptive action of morphine by Ukrain in rodents.
Jagie??o-Wójtowicz E, Kleinrok Z, Chodkowska A, Feldo M, Nowicky JW.
Department of Pharmacology, Medical Academy, Lublin, Poland.
Morphine-induced (0.1 mg/kg s.c.)antinociceptive action was determined in rodents
by using the writhing syndrome, hot plate and tail-flick tests. Ukrain given i.p.
in doses equivalent to 0.05 and 0.1 LD50 did not affect the reactivity of the
mice in the writhing syndrome test. Only in a dose of 0.1 LD50 did Ukrain produce
an antinociceptive effect in the hot-plate and tail-flick tests. Ukrain
significantly enhanced the antinociceptive effect of morphine in the hot-plate
and tail-flick tests. The action of morphine was significantly suppressed by
Ukrain in the writhing syndrome test in mice. These results indicated that Ukrain
modified the antinociceptive action of morphine.