The effects of thiophosphoric acid (Ukrain) on cervical cancer, stage IB bulky

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Drugs Exp Clin Res. 1992;18 Suppl:69-72.

The effects of thiophosphoric acid (Ukrain) on cervical cancer, stage IB bulky.

Pengsaa P, Wongpratoom W, Vatanasapt V, Udomthavornsuk B, Mairieng E,
Tangvorapongchai V, Pesi M, Krusan S, Boonvisoot V, Nowicky JW.

Department of Obstectrics and Gynaecology, Faculty of Medicine, Khon Kaen
University, Thailand.

This study was carried out to determine the clinical and immune response of a
stage IB voluminous uterine cervical cancer to thiophosphoric acid alkaloid
derivatives from Chelidoniium majus L. (Ukrain). The drugs were administered 10
mg intramuscularly every other day, for up to 10 injections. The two largest
diameters and tumour volumes were measured and laboratory and immunological tests
were performed before and after Ukrain administration. The patients were then
operated on with type III Piver's radical hysterectomy. Three out of nine
eligible cases had partial responses while six cases remained stable. Decreased
total B lymphocytes and suppressor T lymphocytes were observed as well as
increased total numbers of T lymphocytes and helper T lymphocytes. There was no
single case of clinical or haematological toxicity apart from mild nausea. Two
patients were treated with adjuvant radiotherapy due to lymphatic involvement and
all nine patients were still alive at least six months after follow-up.

PMID: 1305048