Blinding Problem with mistletoe

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Many of the doubleblind studies on mistletoe were critisized, because the blinding was unmasked by local skin reactions.
As the skin reactions is an inherent part of mistletoe therapy, it is very hard to come around this problem. This does not have to mean that mistletoe therapy do not work.
The authors use this as a central argument to state that there is a lack pof evidence for mistletoe therapy.
We simply has to find a methodology suiting the particular therapy, just as you cannot make placebo operations or placebo diets, but anyway can find surgery and diet to be useful treatments.