Hyperthermia and Immunity. A Brief Overview

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In Vivo
November 1, 2006

vol. 20

no. 6A

689-695

  1. GIANFRANCO BARONZIO1,
  2. ALBERTO GRAMAGLIA1 and
  3. GIANMARIA FIORENTINI2

+Author Affiliations

  1. 1Radiotherapy Hyperthermia Department, Policlinico di Monza, Via Amati, 111, 20052 Monza
  2. 2Oncology Department, San Giuseppe Hospital, Antica Sede via Paladini, 40,50053, Empoli (FI), Italy

  1. Correspondence to: Gianfranco Baronzio, Radiotherapy Hyperthermia Department, Policlinico di Monza, Via Amati, 111, 20052 Monza, Italy. e-mail:
    barongf@intercom.it

Abstract
After
many years, hyperthermia (HT) is experiencing a new resurgence as seen
by the positive results of many randomized trials all over the world.
Tumour immunity similarly is suggested as the fourth modality of
therapy for metastatic tumours from renal carcinoma and melanoma. An
overwhelming amount of data from animal models and human patients
indicate that whole body and locoregional hyperthermia exerts many
biological and therapeutic effects on immune competent cells and
cytokines. Among these effects, hyperthermia has recently been
demonstrated to enhance the antigen presentation and consequently the
activity of dendritic cells. This improvement is obtained through
several mechanisms: a) increased lymphocyte recruitment and trafficking
into the tumour area; b) increased immunogenicity of heat treated
tumour cells; and c) increased production of the heat-shock proteins
and costimulatory molecules. The effects and mechanisms of HT on
immunity, lymphocyte recruitment and dendritic cell stimulation by heat
shock proteins are reviewed here. Moreover the use of HT as an innate
immunity booster in association with biological response modifiers is
suggested.