Local ultrasound hyperthermia as a component of radiotherapy for osteogenic sarcoma of tubular bones in children and adolescents

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Vopr Onkol. 2007;53(5):584-8.
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[Local
ultrasound hyperthermia as a component of radiotherapy for osteogenic
sarcoma of tubular bones in children and adolescents]
[Article in Russian]
Mardynski? IuS, Lopatin VF, Bizer VA.
An
evaluation of the end results of combined treatment for osteogenic
sarcoma by standard chemoradiotherapy (n = 66) and novel thermochemical
therapy (n = 108) using local ultrasound hyperthermia (total
number--174) demonstrated their dependence on the temperature range in
target tumor tissues. Use of subhypertemperatures of 39--41-45 deg.C
(TTD--36 Gy) did not improve the results of treatment. However, 41-45
deg.C (TTD--36 Gy) was followed by a significant increase in 3- and
5-year survival and improved quality of life in cured patients as
compared with those receiving standard radiotherapy (TTD--60-110 Gy).
Hyperthermic therapeutic effect in osteogenic sarcoma depends on
certain conditions. Effective temperatures can generally be reached in
patients with relatively large-size tumors and rather thin coats of
subcutaneous fat.