Effects of a high molecular mass Convolvulus arvensis extract on tumor growth and angiogenesis.

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P R Health Sci J. 2002 Dec;21(4):323-8.

Effects of a high molecular mass Convolvulus arvensis extract on tumor growth and angiogenesis.
Meng XL, Riordan NH, Casciari JJ, Zhu Y, Zhong J, González MJ, Miranda-Massari JR, Riordan HD.
Bio-Communications
Research Institute, Center for the Improvement of Human Functioning,
3100 North Hillside Avenue, Wichita, KS 67219, USA.
BACKGROUND:
Plant materials represent promising sources of anti-cancer agents. We
developed and tested a novel extract from the ubiquitous plant
Convolvulus arvensis.
MATERIALS AND METHODS: Convolvulus arvensis
components were extracted in boiling water, and small molecules were
removed by high-pressure filtration. The extract's biological activity
was assessed by measuring its effects on S-180 fibrosarcoma growth in
Kun Ming mice and on heparin-induced angiogenesis in chick embryos. We
also examined the extract's effects on lymphocytes ex vivo and tumor
cell growth in vitro.
RESULTS: The extract (primarily proteins and
polysaccharides) inhibited tumor growth in a dose-dependent fashion
when administered orally. At the highest dose tested, 200 mg/kg/day,
tumor growth was inhibited by roughly seventy percent. Subcutaneous or
intraperitoneal administration at 50 mg/kg/day also inhibited tumor
growth by over seventy percent. The extract's acute LD50 in Kun Ming
mice was 500 mg/kg/day when injected, indicating that tumor growth
inhibition occurred at non-toxic doses. It inhibited angiogenesis in
chick embryos, improved lymphocyte survival ex vivo, and enhanced yeast
phagocytosis, but did not kill tumor cells in culture.
CONCLUSION: High
molecular mass extract deserves further study as an anti-cancer agent.PMID: 12572240 [PubMed - indexed for MEDLINE]