Effects of a high molecular mass Convolvulus arvensis extract on tumor growth and angiogenesis.

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P R Health Sci J. 2002 Dec;21(4):323-8.

Effects of a high molecular mass Convolvulus arvensis extract on tumor growth and angiogenesis.
Meng XL, Riordan NH, Casciari JJ, Zhu Y, Zhong J, González MJ, Miranda-Massari JR, Riordan HD.
Research Institute, Center for the Improvement of Human Functioning,
3100 North Hillside Avenue, Wichita, KS 67219, USA.
Plant materials represent promising sources of anti-cancer agents. We
developed and tested a novel extract from the ubiquitous plant
Convolvulus arvensis.
MATERIALS AND METHODS: Convolvulus arvensis
components were extracted in boiling water, and small molecules were
removed by high-pressure filtration. The extract's biological activity
was assessed by measuring its effects on S-180 fibrosarcoma growth in
Kun Ming mice and on heparin-induced angiogenesis in chick embryos. We
also examined the extract's effects on lymphocytes ex vivo and tumor
cell growth in vitro.
RESULTS: The extract (primarily proteins and
polysaccharides) inhibited tumor growth in a dose-dependent fashion
when administered orally. At the highest dose tested, 200 mg/kg/day,
tumor growth was inhibited by roughly seventy percent. Subcutaneous or
intraperitoneal administration at 50 mg/kg/day also inhibited tumor
growth by over seventy percent. The extract's acute LD50 in Kun Ming
mice was 500 mg/kg/day when injected, indicating that tumor growth
inhibition occurred at non-toxic doses. It inhibited angiogenesis in
chick embryos, improved lymphocyte survival ex vivo, and enhanced yeast
phagocytosis, but did not kill tumor cells in culture.
molecular mass extract deserves further study as an anti-cancer agent.PMID: 12572240 [PubMed - indexed for MEDLINE]