Fruit and berries--interactions with drugs

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Tidsskr Nor Laegeforen. 2007 Dec 13;127(24):3218-20.

[Fruit and berries--interactions with drugs]

[Article in Norwegian]
Molden E, Spigset O.
Farmasøytisk institutt Universitetet i Oslo Postboks 1068 Blindern 0316 Oslo. espen.moldenfarmasi.uio.no
Diet
is one of many factors that could alter the pharmacokinetics of drugs.
Several fruits and berries have recently been shown to contain agents
that affect drug-metabolizing enzymes. Grapefruit is the most
well-known example, but also Sevillian orange, pomelo and star fruit
contain agents that inhibit cytochrome P450 3A4 (CYP3A4), which is the
most important enzyme in drug metabolism. The present article reviews
published information on potential interactions between drugs and
fruits/berries, with main focus on inhibition and induction of
metabolizing enzymes.