Carbohydr Res. 2008 Sep 26. [Epub ahead of print]
Modified citrus pectin anti-metastatic properties: one bullet, multiple targets.
Glinsky VV, Raz A.
S. Truman Memorial Veterans' Hospital, Columbia, MO 65201, USA;
Department of Pathology and Anatomical Sciences, University of
Missouri, Columbia, MO 65212, USA.
minireview, we examine the ability of modified citrus pectin (MCP), a
complex water soluble indigestible polysaccharide obtained from the
peel and pulp of citrus fruits and modified by means of high pH and
temperature treatment, to affect numerous rate-limiting steps in cancer
metastasis. The anti-adhesive properties of MCP as well as its
potential for increasing apoptotic responses of tumor cells to
chemotherapy by inhibiting galectin-3 anti-apoptotic function are
discussed in the light of a potential use of this carbohydrate-based
substance in the treatment of multiple human malignancies.