- Nippon Ronen Igakkai Zasshi. 2009 May;46(3):264-8.
[A case of metronomic chemotherapy as an alternative cancer therapy for palliation]
[Article in Japanese]
Yamashita K, Nabeshima A, Kondo H, Nagao T, Hara Y, Naritomi Y.
82-year-old woman underwent colostomy and standard chemotherapy using
tegafur/uracil and calcium folinate under a diagnosis of colon cancer.
Recurrence occurred, with pulmonary metastasis, hydroureter, and
numbness in the low extremities. When admitted to our palliative care
unit, she and her family wanted to have mild and minimally toxic
chemotherapy. We initiated oral combination of UFT and cyclophosphamide
metronomic chemotherapy. She was able to eat for more than 7 months.
Her body weight was maintained, and tumor markers were kept suprressed
until her death. This case suggests the usefulness of an oral
anti-cancer drug low dose metronomic chemotherapy as an alternative
cancer therapy in elderly cancer patients requiring palliation.