N-acetylcysteine inhibits proliferation, adhesion, migration and invasion of human bladder cancer cells.

Primary tabs

field_vote: 
Average: 8 (1 vote)
Publication type: 
Therapeutic intervention: 
Therapeutic Substance(s): 
References: 

J Med Assoc Thai. 2009 Sep;92(9):1171-7.
N-acetylcysteine inhibits proliferation, adhesion, migration and invasion of human bladder cancer cells.

Supabphol A, Muangman V, Chavasiri W, Supabphol R, Gritsanapan W.
Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
OBJECTIVE:
Bladder cancer is not only a major public health and economically
burden for the patients but also a major clinical impact for Thai
urologists. The authors' aim was to study the anti-metastatic effect of
N-acetylcysteine (NAC), one of the cheap, safe and widely used
over-the-counter-drugs in Thailand, on the human bladder cancer cells.

MATERIAL AND METHOD: Effects of NAC at various concentrations on the
growth, adhesion, migration, and invasion of the human bladder cancer
cell line were assessed in vitro. RESULTS: NAC at the concentrations of
5, 10, 20 and 30 mM could directly and significantly inhibit the
growth, adhesion, migration, and invasion of the human bladder cancer
cells in a dose-dependent manner The 50% inhibitory concentration
(IC50) value for cell viability was 33.33 +/- 0.78 mM. The inhibitory
effects on migration, invasion and adhesion properties of the cancer
cells were dramatically observed at the concentrations of > or = 10,
> or = 20 and > or = 30 mM respectively.
CONCLUSION: NAC has an
anti-metastatic effect on the human bladder cancer cells by inhibiting
their growth, adhesion, migration, and invasion properties. This
implies the high possibility that the urologists may apply the results
to use it intravesically before, during and after the transurethral
resection of bladder tumour in addition to its conventional usage by
oral and parenteral routes.