- Neurobiol Dis. 2000 Aug;7(4):483-91.
- Erratum in:
- Neurobiol Dis 2001 Feb;8(1):181.
Enhanced proliferation and potassium conductance of Schwann cells isolated from NF2 schwannomas can be reduced by quinidine.
Rosenbaum C, Kamleiter M, Grafe P, Kluwe L, Mautner V, Müller HW, Hanemann CO.
Department of Neurology, Heinrich-Heine University, Duesseldorf, Germany.
type 2 (NF2) is an autosomal dominant disease that is characterized
mainly by schwannomas, as well as menigiomas and gliomas. The NF2 gene
product merlin/schwannomin acts as a tumor suppressor. Schwann cells
derived from NF2 schwannomas showed an enhanced proliferation rate, and
electrophysological studies revealed larger K(+) outward currents as
compared with controls. Schwann cells isolated from schwannomas of NF2
patients or multiorgan donors were treated with different
concentrations of the K(+) current blockers quinidine,
tetraethylammonium chloride, and 4-aminopyridine and K(+) outward
currents and proliferation rates of these cells were compared. K(+)
outward currents of both cell types can be blocked by quinidine.
Importantly, treatment with quinidine reduces proliferation of NF2
Schwann cells in a concentration dependent manner but did not reduce
proliferation of normal Schwann cells. Therefore, the use of quinidine
or quinidine-like components would possibly provide a novel adjuvant
therapeutic option for NF2 patients to slow down or freeze growth of
schwannomas. Copyright 2000 Academic Press.