Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase

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Life Sci. 2003 May 9;72(25):2853-61.

Annonacin,
a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase
and causes cytotoxicity in a Bax- and caspase-3-related pathway.

 
Yuan SS, Chang HL, Chen HW, Yeh YT, Kao YH, Lin KH, Wu YC, Su JH.
Department of Obstetrics and Gynecology, Kaohsiung Medical University, Kaohsiung, Taiwan 807, ROC.

Annonaceous
acetogenins are a group of potential anti-neoplastic agents isolated
from Annonaceae plants. In this study, we purified annonacin, a
cytotoxic mono-tetrahydrofuran acetogenin, from the seeds of Annona
reticulata and analyzed its biological effects. Herein, we have shown
that annonacin caused significant cell death in various cancer cell
lines. T24 bladder cancer cells at the S phase were more vulnerable to
the cytotoxicity of annonacin. Furthermore, annonacin activated p21 in
a p53-independent manner and arrested T24 cells at the G1 phase. It
also induced Bax expression, enhanced caspase-3 activity, and caused
apoptotic cell death in T24 cells. In summary, these results suggest
that annonacin is potentially a promising anti-cancer compound.