In Vitro Experiment

Title Average Ratingsort ascending
Metronomic 5-fluorouracil, oxaliplatin and irinotecan in colorectal cancer. 90.00%
Vitamin D binding protein-macrophage activating factor directly inhibits proliferation, migration, and uPAR expression of prosta 90.00%
Sanguinarine-induced apoptosis in human leukemia U937 cells via Bcl-2 downregulation and caspase-3 activation. 90.00%
Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of the AMPA receptor. 90.00%
Chemical analyses of Ukrain, a semi-synthetic Chelidonium majus alkaloid derivative, fail to confirm its trimeric structure 90.00%
Cystatin C in LS lymphosarcoma and HA-1 hepatoma treated with Ukrain and cyclophosphamide and involvement of apoptosis. 90.00%
20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and 90.00%
In-vitro toxicity of Ukrain against human Ewing tumor cell lines. 90.00%
Effect of Ukrain on the growth and metastasizing of Lewis carcinoma in C57BL/6 mice 90.00%
Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a 90.00%
Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. 85.00%
Effect of Ukrain on matrix metalloproteinase-2 and Secreted Protein Acidic and Rich in Cysteine (SPARC) expression in human.... 80.00%
Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L. protects human fibroblasts but not human tumour ce 80.00%
Ukrain acts by inhibition of tubulin polymerization in normal and malignant cell lines. 80.00%
Cytochrome P-450 2C9 sensitizes human prostate tumor cells to cyclophosphamide via a bystander effect. 80.00%
In vitro cytotoxicity of combinations of dichloroacetate with anticancer platinum compounds 80.00%
A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort 80.00%
Metabolic-targeted therapy with dichloroacetate (DCA): a novel treatment strategy to improve the outcome of photodynamic therapy 80.00%
The influence of glucose, succinate, pH of the medium and higher temperature on the cytotoxic activity of the preparation Ukrain 80.00%
Antiangiogenic potency of various chemotherapeutic drugs for metronomic chemotherapy. 80.00%
Metformin is a potent inhibitor of endometrial cancer cell proliferation-implications for a novel treatment strategy. 80.00%
Sanguinarine suppresses prostate tumor growth and inhibits survivin expression. 80.00%
Effect of some isoquinoline alkaloids on enzymatic activity of acetylcholinesterase and monoamine oxidase 80.00%
ROS production and angiogenic regulation by macrophages in response to heat therapy. 80.00%
N-acetylcysteine inhibits proliferation, adhesion, migration and invasion of human bladder cancer cells. 80.00%
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission 80.00%
Evaluation of anticancer activities of benzo phenanthridine alkaloid sanguinarine in oral squamous cell carcinoma cell line. 80.00%
Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway. 80.00%
National Cancer Institute, National Institute of Health: Developmental Therapeutics Program. NSC 631570: results of the Human Ce 80.00%
Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met. 80.00%
Sanguinarine induces apoptosis of human pancreatic carcinoma AsPC-1 and BxPC-3 cells via modulations in Bcl-2 family proteins 80.00%
The antimitotic effects of Ukrain, a Chelidonium majus alkaloid derivative, are reversible in vitro. 80.00%
Disulfiram induces copper-dependent stimulation of reactive oxygen species and activation of the extrinsic apoptotic pathway in 80.00%
Inhibition of liver mitochondrial monoamine oxidase activity by alkaloids isolated from Chelidonium and Macleaya and by their de 80.00%
Induction of apoptosis in cultured Chinese hamster ovary cells by Ukrain and its synergistic action with etoposide. 80.00%
Induced G2/M arrest and apoptosis in human epidermoid carcinoma cell lines by semisynthetic drug Ukrain 80.00%
Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expressio 80.00%
Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells. 80.00%
Effect of emodin combined gemcitabine on the growth and apoptosis of pancreatic cancer cell line BxPC-3 in vitro 80.00%
In vitro induction of apoptotic cell death in chronic lymphocytic leukemia by two natural products: preliminary study 70.00%
Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in th 70.00%
Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes 70.00%
Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor expression in chronic myeloid leukemi 70.00%
The inhibition of glioma growth in vitro and in vivo by a chitosan/ellagic acid composite biomaterial. 70.00%
Synergistic cytotoxicity of artemisinin and sodium butyrate on human cancer cells. 70.00%
Anticancer Effect of Dihydroartemisinin (DHA) in a Pancreatic Tumor Model Evaluated by Conventional Methods and Optical Imaging. 70.00%
The effects of chelidonine on tubulin polymerisation, cell cycle progression and selected signal transmission pathways 70.00%
NF-kappaB does not influence the induction of apoptosis by Ukrain. 70.00%
Selective inhibition of in vitro cell growth by the anti-tumour drug Ukrain 70.00%
Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer. 70.00%
Fibronectin and laminin increase resistance to ionizing radiation and the cytotoxic drug Ukrain in human tumour and normal cells 60.00%
Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase path-- 60.00%
Transferrin receptor-dependent cytotoxicity of artemisinin-transferrin conjugates on prostate cancer cells and induction of 60.00%
The influence of the novel drug Ukrain on hemo- and immunopoiesis at the time of its maximum radioprotective effect 60.00%
Bcl-2 overexpression protects human keratinocyte cells from Ukrain-induced apoptosis but not from G2/M arrest. 60.00%
1alpha,25-dihydroxyvitamin D(3) (calcitriol) and its analogue, 19-nor-1alpha,25(OH)(2)D(2), potentiate the effects of ionising.. 60.00%
Radiomodification effects of Ukrain, a cytostatic and immunomodulating drug, on intracellular glucocorticoid reception during sh 60.00%
Metronomic administration of ibandronate and its anti-angiogenic effects in vitro. 60.00%
Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and m 60.00%
Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo 60.00%
Gallic acid, a major component of Toona sinensis leaf extracts, contains a ROS-mediated anti-cancer activity in human prostate 60.00%
Cysteine proteinases and their inhibitors in the development of mouse HA-1 hepatoma and antineoplastic therapy 60.00%
Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glyc 60.00%
Enhanced proliferation and potassium conductance of Schwann cells isolated from NF2 schwannomas can be reduced by quinidine. 60.00%
Synergistic antitumor effect of dichloroacetate in combination with 5-fluorouracil in colorectal cancer. 60.00%
A method for determination of Ukrain in blood plasma for monitoring and pharmacokinetic study 50.00%
A study of the influence of a novel drug Ukrain on in vivo effects of low-dose ionizing radiation 50.00%
Five novel mono-tetrahydrofuran ring acetogenins from the seeds of Annona muricata. 50.00%
Comparative in vitro study of the effects of the new antitumor drug Ukrain and several cytostatic agents on the thiol groups in 50.00%
Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosp 50.00%
c-myc amplification is associated with HER2 amplification and closely linked with cell proliferation in tissue microarray of non 50.00%
Ukrain modulates glial fibrillary acidic protein, but not connexin 43 expression, and induces apoptosis in human cultured gliobl 50.00%
Ukrain (NSC-631570) influences on bone status: a review. 50.00%
Biological activity of some thiophosphamide derivatives of alkaloids with respect to influenza virus 50.00%
Influence of Ukrain on the nuclear thyroid hormone receptors after short-term gamma-irradiation. 50.00%
Inhibition of angiogenesis by non-toxic doses of temozolomide. 50.00%
Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells. 50.00%
Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR. 50.00%
Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide. 50.00%
Inhibition of c-Met as a therapeutic strategy for esophageal adenocarcinoma. 50.00%
Effect of alkaloid sanguinarine and a pharmaceutical preparation ukrain on modulation of vesicular membrane fusion and actin.... 50.00%
Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase 50.00%
Enhancement of macrophage tumouricidal activity by the alkaloid derivative 40.00%
Ukrain: acute toxicity after intravenous, intramuscular and oral administration in rats 40.00%
Inhibition of MIF Leads to Cell Cycle Arrest and Apoptosis in Pancreatic Cancer Cells. 40.00%
Hepatocyte growth factor as inducer of gefitinib resistance in non-small cell lung cancer harboring EGFR activating mutations. 40.00%
In vitro and in vivo antiproliferative activity of laherradurin and cherimolin-2 of Annona diversifolia Saff. 40.00%
Kinetics study on markers of the immune system by gene expression profiling of an in vivo heated tumor. 40.00%
Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of m 30.00%
Cysteine proteinase inhibitor level in tumor and normal tissues in control and cured mice. 30.00%
Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer. 20.00%
Effect of Ukrain on human liver alcohol dehydrogenase activity in vitro. 0.00%
Induced apoptosis in human prostate cancer cell line LNCaP by Ukrain. 0.00%
Evaluation of mutagenic, genotoxic and transforming properties of Ukrain 0.00%